Safer with MTD≥15g/kg 

Does not mask Vitamin B12 deficiency

Can cross Blood-brain barrier

Absorb with Intestinal instead of Liver

Be able to penetrate cells without being metabolized

Can be absorbed for Variation in MTHFR genotype

Magnafolate is the unique patent protected C crystalline Calcium L-5-methyltetrahydrofolate (L-5-MTHF Ca) which can get the purest and most stable bio-active folate.

Magnafolate can be absorbed directly, no metabolism, suitable for all kinds of people including MTHFR gene mutation. 
while food folate and folic acid need to undergo several biochemical conversions in the body to become L-5-MTHF.